Description
Product Characteristics: For the quantitative determination of human secreted frizzled-related protein 1 (SFRP1) concentrations in serum, plasma, cell culture supernates, tissue homogenates and cell lysates.
Target Information: This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling\, epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]